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On the continuum of cannabis-related developmental neurotoxicity, there is growing evidence that psychological health may be particularly vulnerable to the adverse effects of in utero exposure.
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Preclinical animal model systems provide an important bridge between brain and behavior, allowing for the identification of neural pathways and processes that underlie postnatal changes in exposed offspring Thompson et al.
Human Cannabinoid Pharmacokinetics. In a study of maternal cannabis use and effects on fetal growth, decrements in birthweight and neonatal head circumference were associated with prenatal exposure but only when data were restricted to women with a positive urine assay for cannabis Zuckerman et al.
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Speed Bprnheim terms and conditions vs. Cognitive impairments in exposed animals were accompanied by changes in cortical gene expression that suggest alterations in glutamatergic neurotransmission. Pharmacol Ther. Differential effects on cognitive functioning in to year-olds prenatally viewz to cigarettes and marihuana. These minor species differences are, however, unlikely to affect the validity of giews model species as nor-THC-COOH is an inactive metabolite.
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Marijuana use during pregnancy and perinatal risk factors. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.
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